Activation of NF-kB mediates up-regulation of cerebellar and hypothalamic pro-inflammatory chemokines (RANTES and MCP-1) and cytokines (TNF-α, IL-1β, IL-6) in acute edible camphor administration

Simple item page
dc.contributor.authorSomade OT
dc.contributor.authorAjayi BO
dc.contributor.authorAdeyi OE
dc.contributor.authorAina BO
dc.contributor.authorDavid BO
dc.contributor.authorSodiya ID
dc.date.accessioned2022-07-28T19:33:03Z
dc.date.available2022-07-28T19:33:03Z
dc.date.issued2019
dc.descriptionScientific African
dc.description.abstractEdible camphor (EC) infusions are continually used as an aphrodisiac among other roles. In previous studies, EC had been reported to cause convulsion and seizure in rats. There is a dearth of information associating or relating its consumption to brain inflammation. Therefore, we investigated the effect of various doses of EC in an acute study, on hypothalamic and cerebellar levels of some pro-inflammatory cytokines and chemokines in male Wistar rats. Following administration, cerebellar levels of tumor necrosis factor-alpha (TNF-α), interleukin 1 beta (IL-1β), and interleukin 6 (IL-6) were significantly increased by 2000 and 4000 mg/kg EC, while hypothalamic TNF-α and IL-1β levels were significantly elevated by all the tested doses, and IL-6 level by only 2000 and 4000 mg/kg when compared with control. Besides, EC administration resulted in a significant increase in the expressions of cerebellar and hypothalamic nuclear factor kappa B (NF-kB), cyclooxygenase 2 (COX-2), regulated upon activation normal T cell expressed and secreted (RANTES), and monocyte chemo-attractant protein 1 (MCP-1) in a dose-dependent manner compared with control. Therefore, the misuse and overconsumption of EC could trigger cerebellar and hypothalamic inflammation via EC-induced activation of NF-kB and up-regulation of pro-inflammatory mediators.
dc.identifier.citation10.1016/j.sciaf.2019.e00114
dc.identifier.issn2468-2276
dc.identifier.urihttps://nerd.ethesis.ng/handle/123456789/448
dc.language.isoen
dc.subjectEdible camphor
dc.subjectCerebellum
dc.subjectHypothalamus
dc.subjectPro-inflammation
dc.subjectCytokines
dc.subjectChemokines
dc.titleActivation of NF-kB mediates up-regulation of cerebellar and hypothalamic pro-inflammatory chemokines (RANTES and MCP-1) and cytokines (TNF-α, IL-1β, IL-6) in acute edible camphor administration
dc.title.alternativeOther Titles
dc.typeArticle
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Activation-of-NF-kB-mediates-up-regulation-of-cerebellar-and-hypo_2019_Scien.pdf
Size:
4.1 MB
Format:
Adobe Portable Document Format
Download
Collections
Journal Article