Quantitative distribution and interaction of Salmonella Zega with host cells in visceral organs of chickens infected orally, intraperitoneally and per cloaca

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dc.contributor.authorMshelbwala FM
dc.contributor.authorIbrahim ND
dc.contributor.authorSaidu SN
dc.contributor.authorBabatunde EG
dc.contributor.authorKadiri AK
dc.contributor.authorThomas FC
dc.contributor.authorKwanashie CN
dc.contributor.authorAgbaje M
dc.date.accessioned2022-07-28T20:16:15Z
dc.date.available2022-07-28T20:16:15Z
dc.date.issued2020
dc.descriptionHeliyon
dc.description.abstractImmunohistochemical study of the visceral organs of chickens experimentally infected with Salmonella Zega by three routes was carried out to compare the quantitative distribution and interaction of the organism with host cells. 100 birds comprising of 2 week-old chickens were divided into 4 groups of 25 each. Group A was inoculated orally, group B intraperitoneally, group C were administered per cloaca and D were not inoculated and served as control. All the infected birds were inoculated with 0.2 ml of 1 × 108 cfu of the bacteria. Two birds from each group were sacrificed every 24 h post infection. Samples of visceral organs were collected for immunohistochemistry. The distribution of Salmonella Zega in every organ was taken as Mean ± SD of the number of foci of immunoreactions and Compared using a 2-way ANOVA. The interaction of Salmonella Zega with host cells was determined by taking the percentage of the days post infection in which immunoreactions were detected in host cells in each route of infection. The distribution of the organism was highest in the lung of intraperitoneally infected chickens (83.95 ± 27.89) and lowest in the heart (5.21 ± 3.65) of chickens that were infected per cloaca. The highest percentage of interaction of Salmonella Zega was recorded in the epithelial (100%) and blood (100%) cells in all the routes of infection. There were variations in the distribution of Salmonella Zega in visceral organs of chickens but the level of interactions with host cells were similar even when infected through different routes.
dc.identifier.citation10.1016/j.heliyon.2020.e03180
dc.identifier.issn2405-8440
dc.identifier.urihttps://nerd.ethesis.ng/handle/123456789/532
dc.language.isoen
dc.subjectAgriculture
dc.subjectBiological sciences
dc.subjectEnvironmental science
dc.subjectHealth sciences
dc.subjectVeterinary medicine
dc.subjectZega
dc.subjectInfection
dc.subjectDistribution
dc.subjectInteraction
dc.subjectOrgans
dc.subjectCells
dc.subjectChickens
dc.titleQuantitative distribution and interaction of Salmonella Zega with host cells in visceral organs of chickens infected orally, intraperitoneally and per cloaca
dc.typeArticle
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