Ethanolic extract of Anogeissus leiocarpus ameliorates hyperglycaemia, hepato-renal damage, deranged electrolytes and acid-base balance in alloxan-induced diabetes in dogs

Simple item page
dc.contributor.authorNum-Adom SM
dc.contributor.authorAdamu S
dc.contributor.authorAluwong T
dc.contributor.authorOgbuagu NE
dc.contributor.authorUmar IA
dc.contributor.authorEsievo KA
dc.date.accessioned2022-07-28T20:16:13Z
dc.date.available2022-07-28T20:16:13Z
dc.date.issued2022
dc.descriptionScientific African
dc.description.abstractAnti-diabetic effects of ethanolic extract of stem bark of Anogeissus leiocarpus were investigated in alloxan monohydrate-induced acute type 1 diabetes mellitus (TIDM) extending into chronicity and organic damages in 12 adult Nigerian indigenous dogs assigned 4 groups of 3 each, namely: non-diabetic controls (ND), diabetic untreated (DU), diabetic insulin-treated (DI) and diabetic extract-treated (DE). All parameters were analysed using standard procedures. Hyperglycaemia occurred in the diabetic dogs; blood glucose significantly (P < 0.001) increased in the DU group compared with other groups. The ethanolic extract significantly (P < 0.001) decreased blood glucose levels like insulin (P < 0.002). Haematology revealed macrocytic normochromic anaemia; significantly decreased PCV (P < 0.001), Hb (P < 0.001), RBC (P < 0.001), WBC (P < 0.05). Neutrophils (P < 0.05) and lymphocytes (P < 0.05) in DU. Organic damage biomarkers, ALT, ALP activities (P < 0.05), albumin and urea concentrations significantly increased in DU. Hyponatremia, loss of bicarbonates (P < 0.05), hyperkalemia and hyperchloridaemia occurred in DU. The ethanolic extract corrected these haemato-biochemical abberations and produced positive anion-gap like the non-diabetic controls while those of DU and DI were negative with more bicarbonates retention in DI group. While hyperglycaemia relapsed after insulin withdrawal, normoglycaemia remained without reoccurrence of hyperglycaemia after withdrawal of A. leiocarpus extract. This alloxan-induced TIDM in Nigerian indigenous dogs showed that ethanolic extract of A. leiocarpus reduces blood glucose and may prevent development into T2DM.
dc.identifier.citation10.1016/j.sciaf.2022.e01183
dc.identifier.issn2468-2276
dc.identifier.urihttps://nerd.ethesis.ng/handle/123456789/514
dc.language.isoen
dc.subjectDiabetes mellitus
dc.subjectHyperglycaemia
dc.subjectAlloxan monohydrate
dc.subjectElectrolytes
dc.titleEthanolic extract of Anogeissus leiocarpus ameliorates hyperglycaemia, hepato-renal damage, deranged electrolytes and acid-base balance in alloxan-induced diabetes in dogs
dc.typeArticle
Files
Original bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
Ethanolic-extract-of-Anogeissus-leiocarpus-ameliorates-hyperglyc_2022_Scient.pdf
Size:
492.41 KB
Format:
Adobe Portable Document Format
Download
Collections
Journal Article