Mitigative potentials of methanol leaf extract of Moringa oleifera on chronic carbamazepine-induced haemo-biochemical and thyrotoxicity in male Wistar rats

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dc.contributor.authorAkorede GJ
dc.contributor.authorAmbali SF
dc.contributor.authorOlatunji AO
dc.contributor.authorAremu A
dc.contributor.authorBasiru A
dc.contributor.authorAhmed AO
dc.contributor.authorAzeez MO
dc.contributor.authorAbdulmajeed I
dc.contributor.authorKadir RA
dc.date.accessioned2022-07-26T11:50:18Z
dc.date.available2022-07-26T11:50:18Z
dc.date.issued2022
dc.descriptionPharmacological Research - Modern Chinese Medicine
dc.description.abstractCarbamazepine (CBZ) is commonly used for treating epilepsy and neuropathic pain. This present research was carried out to evaluate ameliorative potentials of methanol leaves extract of Moringa oleifera on chronic CBZ-induced haemotoxicity and thyrotoxicosis in male Wistar rats. 32 adult male Wistar rats were divided into four groups of 8 animals each and exposed to the following regimens: Group I (DW) was administered distilled water (2 ml/kg); group II (MO) was exposed M. oleifera (200 mg/kg); group III (CBZ) was given carbamazepine at 20 mg/kg, while group IV (CBZ+MO) was exposed to carbamazepine (20 mg/kg) then followed by M. oleifera (200 mg/kg) 30 minutes later. The regimens were given once daily for 15 weeks via gavage. Blood and serum samples were evaluated for haematological parameters, liver biochemical enzymes and thyroid hormone. The results revealed that M. oleifera leaves extract mitigate against alteration in parameters measuring haematological, biochemical and thyroid functions. The study concluded that amelioration against CBZ-evoked alteration in haematological indices, biochemical enzymes and thyroid function by M. oleifera leave extract was partly due to its nutritional values and phytochemical constituents that confer protection on blood vascular system, and hypothalamic-pituitary axis.
dc.identifier.citation10.1016/j.prmcm.2022.100055
dc.identifier.issn2667-1425
dc.identifier.urihttps://nerd.ethesis.ng/handle/123456789/261
dc.language.isoen
dc.subjectChronic exposure
dc.subjectcarbamazepine
dc.subjecthaemotoxicity
dc.subjectthyrotoxicosis
dc.subjectMoringa oleifera
dc.titleMitigative potentials of methanol leaf extract of Moringa oleifera on chronic carbamazepine-induced haemo-biochemical and thyrotoxicity in male Wistar rats
dc.typeArticle
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