Toxicological evaluation of repeated administration of povidone iodine in cockerels

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dc.contributor.authorSani D
dc.contributor.authorAbdu PA
dc.contributor.authorMamman M
dc.contributor.authorJolayemi KO
dc.date.accessioned2022-07-28T20:16:16Z
dc.date.available2022-07-28T20:16:16Z
dc.date.issued2022
dc.descriptionToxicology Reports
dc.description.abstractPovidone-iodine (Polidine®) is a synthetic broad-spectrum antiseptic being applied topically to treat wounds and prevent their infection. It has been however reported with the assertions that it is effective in the treatment of infectious bursa disease (IBD) when administered orally by practicing Veterinarians and other poultry handlers. Acute kidney injury has been reported also with povidone iodine ingestion. Hence, in this study, graded dose administration was conducted to ascertain its safety profile. Forty chicks were obtained from a poultry hatchery in Ibadan, Oyo State. They were randomly divided into four (4) groups of ten chicks each. Group I served as negative control, groups II, III and IV were administered Polidine® at 1 mL/50 L, 1 mL/25 L, and 1 mL/10 L of water respectively for 7 days. Blood samples were collected on Days 3 and 7 post administration for determination of haematological and biochemical parameters. Liver and Kidney tissues were harvested following termination of the experiment and processed for histopathological examination. Results revealed no significant (p > 0.05) effect in the haematological and biochemical parameters of cockerels treated with Povidone iodine at 1 mL/50 and 25 L of water. On histopathological examination no lesion was also observed in the liver and kidney tissues of groups I, II and III (normal control, 1 mL/50 and 25 L respectively) when compared to group IV (1 mL PI /50 L of water) where lesions were recorded. Hence, this study has shown the relative safety of povidone iodine at different doses in cockerels.
dc.identifier.citation10.1016/j.toxrep.2022.02.010
dc.identifier.issn2214-7500
dc.identifier.urihttps://nerd.ethesis.ng/handle/123456789/542
dc.language.isoen
dc.subjectCockerels
dc.subjectGraded-doses
dc.subjectHaematology
dc.subjectHistopathology
dc.subjectPovidone iodine
dc.titleToxicological evaluation of repeated administration of povidone iodine in cockerels
dc.typeArticle
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