Hsps70 and 90 protect the heart of hyperthyroid rats via nitric oxide production and VEGF inhibition of apoptosis

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dc.contributor.authorAjayi AF
dc.contributor.authorLateef OM
dc.contributor.authorAdebayo OI
dc.contributor.authorAdebayo ET
dc.date.accessioned2022-07-27T19:26:29Z
dc.date.available2022-07-27T19:26:29Z
dc.date.issued2021
dc.descriptionEndocrine and Metabolic Science
dc.description.abstractBackground . Changes occur in the heart's contractile and metabolic demands during altered thyroid states. The changes may be associated with alterations in the cellular signaling of vascular endothelial growth factors (VEGF) and expressions of heat shock proteins (Hsp). Aim . This study examined the effects of thyroid dysfunction on VEGF, hsp70, and hsp 90 concentrations in the heart tissues of dysthyroid rats. Methods . Wistar rats were allocated into control, hypothyroid (Carbimazole-treated), and hyperthyroid (Levothyroxine-treated) groups randomly (n=7). Thyroid function test, body weight changes, serum creatinine kinase (CK-MB), cardiac troponin I (cTnI) and troponin T (cTnT), NO, VEGF, Hsp70, and Hsp 90 were determined using standard methods. Results . There was a significant increase (P<0.05) in NO, VEGF, Hsp70, and Hsp 90 levels in the hyperthyroid group and reduced expression in the hypothyroid group compared to the control. Carbimazole treatment led to a significant increase in lipid peroxidation and CK-MB level, with a substantial decrease in the superoxide dismutase (SOD) activity in the hypothyroid group. Conclusion . Increased expression of Hsp70 and 90 in hyperthyroid rats' heart tissue play essential roles in protecting the heart from oxidative damage and cardiovascular derangements via enhancement of nitric oxide production and apoptosis inhibition by VEGF.
dc.identifier.citation10.1016/j.endmts.2021.100097
dc.identifier.issn2666-3961
dc.identifier.urihttps://nerd.ethesis.ng/handle/123456789/414
dc.language.isoen
dc.subjectThyroid hormones
dc.subjectOxidative stress
dc.subjectHeat shock proteins
dc.subjectCardiac dysfunction
dc.subjectCardioprotection
dc.titleHsps70 and 90 protect the heart of hyperthyroid rats via nitric oxide production and VEGF inhibition of apoptosis
dc.typeArticle
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