Laser balloon angioplasty: Potential for reduction of the thrombogenicity of the injured arterial wall and for local application of bioprotective materials

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dc.contributor.authorSpears JR
dc.contributor.authorKundu SK
dc.contributor.authorMcMath LP
dc.date.accessioned2022-07-28T19:33:06Z
dc.date.available2022-07-28T19:33:06Z
dc.date.issued1991
dc.descriptionJournal of the American College of Cardiology
dc.description.abstractMitigation of adverse biologic reactivity after balloon angioplasty is necessary before the incidence of restenosis can be appreciably reduced. A brief review of experimental evidence supports the hypothesis that the thrombogenicity of the injured arterial wall can be reduced by a suitable level of thermal denaturation or cross-linking of thrombogenic proteins. In addition, the concept of local pharmacologic therapy, which can be provided with laser balloon angioplasty at the site of arterial injury, is introduced. Preliminary in vitro and in vivo data suggest that guide catheter-injected albumin-heparin conjugates fabricated as waterinsoluble microspheres remain adherent to the injured luminal surface and deeper arterial layers after physical trapping by the inflated balloon and subsequent laser/thermal exposure. The combination of initially adequate luminal morphology, reduction of the thrombogenicity of the injured arterial wall and application of local pharmacologic therapy with laser balloon angioplasty may eventually prove helpful in reducing the incidence of restenosis.
dc.identifier.citation10.1016/0735-1097(91)90956-A
dc.identifier.issn0735-1097
dc.identifier.urihttps://nerd.ethesis.ng/handle/123456789/474
dc.language.isoen
dc.titleLaser balloon angioplasty: Potential for reduction of the thrombogenicity of the injured arterial wall and for local application of bioprotective materials
dc.typeArticle
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