Suppression of uric acid generation and blockade of glutathione dysregulation by L-arginine ameliorates dichlorvos-induced oxidative hepatorenal damage in rats

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dc.contributor.authorSaka WA
dc.contributor.authorAkhigbe RE
dc.contributor.authorAbidoye AO
dc.contributor.authorDare OS
dc.contributor.authorAdekunle AO
dc.date.accessioned2022-07-27T19:26:32Z
dc.date.available2022-07-27T19:26:32Z
dc.date.issued2021
dc.descriptionBiomedicine & Pharmacotherapy
dc.description.abstractDichlorvos is a known risk factor for organ toxicity. The liver and kidney are essential metabolic tissues but it is unclear whether or not there is associated redox dyshomeostasis in both organs in physiological and pathological states. Uric acid accumulation and glutathione dysregulation have been implicated in the aetiopathogenesis of organ damage. The antioxidant potentials of L-arginine have been shown in various conditions. The present study was thus designed to investigate the synchrony in hepatic and renal uric acid and glutathione status in dichlorvos-induced hepatorenal damage and to probe the possible therapeutic role of L-arginine. Twenty-one male Wistar rats were treated with standard rat diet and water, dichlorvos, or dichlorvos and L-arginine. Our findings revealed that dichlorvos significantly impaired hepatic and renal functions, increased hepatic and renal malondialdehyde, but reduced glutathione and activities of superoxide dismutase, catalase, and glutathione peroxidase. These events were accompanied by increased accumulation of plasma, hepatic, and renal uric acid as well as reduced body weight gain, and hepatic and renal weights. Histopathological examinations revealed hepatic and renal architectural derangement and cellular necrosis and degeneration in dichlorvos-exposed rats. Interestingly, L-arginine reversed dichlorvos-induced systemic, hepatic and renal synchronous redox dyshomeostasis. L-arginine administration also improved hepatic and renal cytoarchitecture. It is thus concluded that dichlorvos triggered synchronous uric acid generation and glutathione alterations in the liver and kidney. L-arginine confers protection against dichlorvos-induced hepatorenal damage via suppression of uric acid generation and blockade of glutathione dysregulation.
dc.identifier.citation10.1016/j.biopha.2021.111443
dc.identifier.issn0753-3322
dc.identifier.urihttps://nerd.ethesis.ng/handle/123456789/433
dc.language.isoen
dc.subjectDichlorvos
dc.subjectArginine
dc.subjectGlutathione
dc.subjectUric acid
dc.subjectOxidative stress
dc.subjectToxicity
dc.titleSuppression of uric acid generation and blockade of glutathione dysregulation by L-arginine ameliorates dichlorvos-induced oxidative hepatorenal damage in rats
dc.typeArticle
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