Reversal of acetaminophen-generated oxidative stress and concomitant hepatotoxicity by a phytopharmaceutical product

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dc.contributor.authorAkinmoladun AC
dc.contributor.authorOguntunde KO
dc.contributor.authorOwolabi LO
dc.contributor.authorIlesanmi OB
dc.contributor.authorOgundele JO
dc.contributor.authorOlaleye MT
dc.contributor.authorAkindahunsi AA
dc.date.accessioned2022-07-27T16:38:38Z
dc.date.available2022-07-27T16:38:38Z
dc.date.issued2017
dc.descriptionFood Science and Human Wellness
dc.description.abstractThe increasing popularity of herbal medicine and the well-established health benefits of phytochemicals have spurred the multiplicity of nutraceutical and phytopharmaceutical products. In this study, Trévo™, a nutraceutical and phytopharmaceutical product, was evaluated for beneficial effects in acetaminophen-induced hepatic toxicity in Wistar rats. Animals received Trévo™ (1.5mL/kg, 3.0mL/kg or 4.5mL/kg) orally for 14 days. Hepatotoxicity was induced by the oral administration of acetaminophen (2g/kg), 24h prior to sacrifice. Biochemical liver function tests, oxidative stress indicators and histoarchitectural changes were evaluated. Acetaminophen administration occasioned significant increase (P<0.05) in serum bilirubin level and activities of the aminotransferases, alkaline phosphatase, γ-glutamyltransferase and lactate dehydrogenase accompanied by a significant decrease (P<0.05) in albumin level as well as histopathological alterations in liver sections. Promotion of hepatic oxidative stress by acetaminophen was revealed by significant (P<0.05) increase in lipid peroxidation, depletion of reduced glutathione, and decrease in superoxide dismutase and catalase activities. Administration of Trévo™ remarkably ameliorated acetaminophen-induced histopathological alterations and changes in serum and tissue biochemical markers. The protective effect of Trévo™ (4.5mL/kg) was at par with that of Silymarin (25mg/kg). The present study indicates that Trévo™ has notable salubrious effects.
dc.identifier.citation10.1016/j.fshw.2016.11.001
dc.identifier.issn2213-4530
dc.identifier.urihttps://nerd.ethesis.ng/handle/123456789/381
dc.language.isoen
dc.subjectAcetaminophen
dc.subjectAntioxidant activity
dc.subjectHepatoprotection
dc.subjectNutraceutical
dc.subjectHerbal supplement
dc.titleReversal of acetaminophen-generated oxidative stress and concomitant hepatotoxicity by a phytopharmaceutical product
dc.typeArticle
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