Reversal of acetaminophen-generated oxidative stress and concomitant hepatotoxicity by a phytopharmaceutical product
Loading...
Date
2017
Journal Title
Journal ISSN
Volume Title
Publisher
Abstract
The increasing popularity of herbal medicine and the well-established health benefits of phytochemicals have spurred the multiplicity of nutraceutical and phytopharmaceutical products. In this study, Trévo™, a nutraceutical and phytopharmaceutical product, was evaluated for beneficial effects in acetaminophen-induced hepatic toxicity in Wistar rats. Animals received Trévo™ (1.5mL/kg, 3.0mL/kg or 4.5mL/kg) orally for 14 days. Hepatotoxicity was induced by the oral administration of acetaminophen (2g/kg), 24h prior to sacrifice. Biochemical liver function tests, oxidative stress indicators and histoarchitectural changes were evaluated. Acetaminophen administration occasioned significant increase (P<0.05) in serum bilirubin level and activities of the aminotransferases, alkaline phosphatase, γ-glutamyltransferase and lactate dehydrogenase accompanied by a significant decrease (P<0.05) in albumin level as well as histopathological alterations in liver sections. Promotion of hepatic oxidative stress by acetaminophen was revealed by significant (P<0.05) increase in lipid peroxidation, depletion of reduced glutathione, and decrease in superoxide dismutase and catalase activities. Administration of Trévo™ remarkably ameliorated acetaminophen-induced histopathological alterations and changes in serum and tissue biochemical markers. The protective effect of Trévo™ (4.5mL/kg) was at par with that of Silymarin (25mg/kg). The present study indicates that Trévo™ has notable salubrious effects.
Description
Food Science and Human Wellness
Keywords
Acetaminophen, Antioxidant activity, Hepatoprotection, Nutraceutical, Herbal supplement
Citation
10.1016/j.fshw.2016.11.001