Antioxidant activity and protective effects of cocoa and kola nut mistletoe (Globimetula cupulata) against ischemia/reperfusion injury in Langendorff-perfused rat hearts

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dc.contributor.authorAkinmoladun AC
dc.contributor.authorOlowe JA
dc.contributor.authorKomolafe K
dc.contributor.authorOgundele J
dc.contributor.authorOlaleye MT
dc.date.accessioned2022-07-27T16:38:34Z
dc.date.available2022-07-27T16:38:34Z
dc.date.issued2016
dc.descriptionJournal of Food and Drug Analysis
dc.description.abstractProtection against cardiomyocyte damage following ischemia/reperfusion (I/R) injury is highly desirable in patients with ischemic heart disease. Hydromethanol extracts of Globimetula cupulata (mistletoe) growing on cocoa (CGCE) and kola nut (KGCE) trees were assessed for antioxidant content and cardioprotective potential against I/R. Graded concentrations (1–50 μg/mL) of CGCE or KGCE were tested on Langendorff-perfused rat hearts to evaluate the effects on the flow rate, heart rate, and force of cardiac contraction, while another set of hearts were subjected to biochemical analyses. Both extracts showed good antioxidant content and activity, but KGCE (EC50: 24.8±1.8 μg/mL) showed higher hydroxyl radical scavenging activity than CGCE (70.2±4.5 μg/mL). Both extracts at 3 μg/mL reversed (p < 0.001) membrane peroxidation and the significant decrease in nitrite level, coronary flow rate, and superoxide dismutase and catalase activity caused by the I/R cycle. It is concluded that G. cupulata protects against ischemia–reperfusion injury in rat hearts via augmenting endogenous antioxidants and significant restoration of altered hemodynamic parameters.
dc.identifier.citation10.1016/j.jfda.2015.10.007
dc.identifier.issn1021-9498
dc.identifier.urihttps://nerd.ethesis.ng/handle/123456789/355
dc.language.isoen
dc.subjectcardioprotection
dc.subjectischemia
dc.subjectreperfusion
dc.titleAntioxidant activity and protective effects of cocoa and kola nut mistletoe (Globimetula cupulata) against ischemia/reperfusion injury in Langendorff-perfused rat hearts
dc.typeArticle
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