Browsing by Author "Oladipo TA"

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    Field evaluation and confirmation of acute peste des petits ruminant outbreak in a flock of West African dwarf goats in Ibadan, Nigeria
    (2017) Balogun FA; Fasanmi OG; Oladipo TA; Popoola MA; Olona JF; Adeoye YD
    This study utilised epidemiological, haematological, pathological findings and serological detection of specific antibodies to evaluate and confirm a peste des petit ruminants (PPR) outbreak in a herd of West African dwarf (WAD) goats in Ibadan, Nigeria. The morbidity and mortality rates post exposure (PE) were 96% and 60% respectively. Laboratory analyses revealed significant differences (P<0.05) in mean values of the haematological and serum biochemical indices between the PE and control groups. The PE group experienced a significant (P<0.05) increase in white blood cell (WBC), lymphocyte and monocytes after 10days PE; the drop in glucose and high levels of alkaline phosphatase (ALP) and aspartate amino transferase (AST) indicated liver damage, while increased serum creatinine, blood urea nitrogen (BUN) and uric acid arose from kidney impairment. The electrolyte imbalance (potassium, sodium and chloride ions) resulting from the symptomatic diarrhea affected the functionality of the Na+–K+ pump mechanisms, hence pathologic damage to the liver, kidneys, skin, gastrointestinal, respiratory and cardiovascular systems. The competitive enzyme linked immuno-sorbent assay (c-ELISA) detected varying antibody levels in the PPR infected WAD goats; the percent inhibition was highest (P<0.001) in survivors (70.00±1.73), then in contact group (60.00±2.00), and least in infected (23.33±1.53), which were sero-negative. This study confirmed a PPR outbreak in a WAD goat flock in Ibadan, Nigeria.