Browsing by Author "Ojiodu CC"

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    Dataset on part replacement of dipalmitoylphophatidylcholine with locust bean on stimulated tracheobronchial fluid, in vitro bioaccessibility test and modeling of lung deposition of trace elements bound to airborne particulates
    (2020) Olumayede EG; Oguntimehin I; Ojiodu CC; Babalola BM; Ojo A; Adeoye OS; Sodipe OG
    The data presented in this article are related to our work on development of tracheobronchial fluid, in vitro bioaccessibility test and modeling of lung deposition of trace elements bound to airborne particulates [1]. In this article, a neutral modeled tracheobronchial fluid was formulated by partial replacement of some constituents in recipes of previously used lung epithelium fluids with local materials and was used in in vitro bioaccessibility extraction of elements-bound to airborne particulates. Dataset of particulate matters-bound trace elements collected in selected locations Ado – Ekiti is presented and the deposition of elements in different regions of respiratory tracts is estimated using Multiple-path particle deposition (MPPD) mathematic model. The data reveals that the formulated fluid has physical characteristics with superior properties to the existing fluids. The data also shows that bioaccessibility of elements were generally low (<30%) except for Cd and As with relatively moderate values (between 45 and 50%). Additionally, the lung deposition modeling shows that greater percentage of Cd (about 40% of inhaled dose) deposition in the lower alveolar part of the respiratory tract while tracheobronchial and extra-thoracic had 33% and 27% respectively. The data sets can be used as references to analyze data obtained using other formulation.
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    Development of tracheobronchial fluid for in vitro bioaccessibility assessment of particulates-bound trace elements
    (2019) Olumayede EG; Oguntimehin I; Babalola B; Ojiodu CC; Akinyeye RO; Sodipe GO; Uche J; Ojo A
    This study was piloted to evaluate bioaccessibility of particulate-bound trace elements using synthetic epithelia lung fluid; in which dipalmitoylphophatidylcholine was substituted with locus bean gum (LBSFL). The resulting data reveal that no significant change in physicochemical characteristics of the stimulated lung fluid compare with similar synthetic fluids; pH value of 7.3, density (0.998gcm−3), conductivity (13.9 mS m-1), surface viscosity (1.136 × 10-12 pas) and surface tension (50.6 mN m-1). To prove the potential applicability of the fluid in in vitro bioaccessibility test, we compared bioaccessibility of particulates-bound trace elements using this fluid with those of stimulated epithelial lung fluid. Bioaccessibility were relatively low values (<30%) in locus bean substituted lung fluid and stimulated epithelial lung fluid. Specifically, As and Cd had significantly higher bioaccessibility values in locus bean substituted lung fluid than stimulated epithelial lung fluid. The data demonstrate that fluid formulated and used in this study can provide a suitable means of evaluate bioaccessibility of trace elements-bound to airborne particulates. •The fluid was used for assessing bioaccessibility of particulate matters-bound trace elements•The formulated fluid can be applied to study in toxicity assessment•The data can be used for inter-laboratory comparison of bioaccessibility of particulate -bound trace element and could stimulate environmental concerns on the impacts of airborne particulates.