Browsing by Author "Ogunkunle O"
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Item A case series of infantile Pompe disease at the university college hospital Ibadan Nigeria(2022) Folayan OS; Agaja OT; Adebayo BE; Ogunkunle O; Omokhodion SIInfantile Pompe disease is a Glycogen storage disease caused by acid α-1,4 -glucosidase (GAA) enzyme deficiency. The deficiency makes lysosomal glycogen accumulate in cardiac, skeletal, and smooth muscle cells resulting in muscle weakness. Incidence of infantile Pompe disease is high in people of African ancestry, but a discrepancy seems to exist between this incidence and clinical observations. This may be explained by factors that make diagnosis difficult. Underdiagnosis may be reduced if healthcare providers have a high index of suspicion, especially in infants that fail to thrive. We report three cases of infantile Pompe disease seen in our practice and the challenges in diagnosis and treatment. Methods We report 3 cases of infantile Pompe's disease seen in our practice and the challenges encountered in establishing a diagnosis and instituting treatment. Conclusion Pompe disease incidence is high among people of African ancestry, but the high incidence does not reflect in clinical presentations possibly because of under-diagnosis by 1st contact doctors. Weakness, cardiomegaly or cardiomyopathy, breathing difficulty, and delayed motor milestones in a child that is failing to thrive should raise the suspicion and prompt investigation for Pompe disease using the less invasive serum GAA assay. Treatment of the disease is multidisciplinary, and reversal of ventricular hypertrophy occurs with enzyme replacement therapy, this therapy is however not easily accessible from our experience with managing the cases we have reported in this document.Item Effect of Organic Loading Rate on Biogas Yields of Pig Slurry in a Continuously Stirred Tank Reactor at Mesophilic Temperature(2019) Adebayo AO; Jekayinfa SO; Ahmed NA; Ogunkunle ORenewable energy appears to be a way out of the associated challenges of the conventional sources of energy. One of these renewable sources is biogas. Biogas is the gas produced when anaerobic bacteria act on organic matters in the absence of oxygen. Anaerobic digestion has been considered as waste-to-energy technology. In this work, attempt was made to determine the effect of organic Loading Rate (OLR) on biogas production potential of pig slurry using a Continuously-Stirred Tank Reactor (CSTR) operated at mesophilic temperature (37oC). A 12-litre capacity CSTR was loaded with 8 litres pre-cultivated sludge as inoculum, leaving a free space for gas production. The loading of the calculated amount of pig manure into the reactor was commenced at a LR of 1.5goTS/l.d and was increased weekly by 0.5 goTS/l.d until an OLR of 5.0 goTS/l.d was reached. The biogas yields at OLR of 1.5, 2.0, 2.5, 3.0, 3.5, 4.0, 4.5 and 5.0 goTS/l.d were 0.255, 0.190, 0.170, 0.180, 0.170, 0.140, 0.120 and 0.140 m3/kgODM, respectively, with corresponding methane yields of 0.153, 0.12, 0.11, 0.11,0.11, 0.09, 0.08, and 0.09 lCH4/goDM. Biogas yield of 0.255m3/kgoDM was recorded as the highest at an OLR of 1.5 goTS/l.d. Summarily, pig manure was found to be best digested at OLR of 1.5 goTS/l.d in a CSTR at mesophilic temperature.