Browsing by Author "Adebayo ET"

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    An epidemiological study of 270 cases of carcinomas of the head and neck region in a Nigerian tertiary health care facility
    (2017) Fomete B; Agbara R; Adebayo ET; Osunde OD; Adeola DS
    Introduction Oral cancer is the sixth most frequently occurring malignant tumor and is the major cause of morbidity and mortality with high metastatic and invasive tendency. The incidence of oral cancer differs widely in various parts of the world with a range of 2–10 per 100,000 populations per year, approximately 300,000 new cases. Incidence and mortality as a result of oral cancer are higher in developing countries when compared to developed countries. This is the reason for the occurrence of the peak age in later decades of life. Patients and methods All consecutive cases of histologically diagnosed cases of orofacial carcinomas seen at the Maxillofacial Unit, Ahmadu Bello University Teaching Hospital, Shika, Zaria, Nigeria over a 10 year period were retrospectively analyzed. Results Over the study period, a total of 1116 cases of maxillofacial conditions were seen in the unit out of which 270 represented orofacial cancers, giving a prevalence of 24.19%. Of the 270 cases, male accounted for 159(58.9%) while females were 111(41.1%) giving a male to female ratio of 1.43:1. The age ranged from 5 to 90 years, mean (SD), 48.4(16.12) years and patients in the 4th to 6th decades (47.7%) were mostly affected. There was no gender difference in terms of distribution of the tumors according to age. Conclusion Squamous cell carcinoma of the orofacial region has continued to pose great challenges to care givers and practitioners involved in their management.
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    Hsps70 and 90 protect the heart of hyperthyroid rats via nitric oxide production and VEGF inhibition of apoptosis
    (2021) Ajayi AF; Lateef OM; Adebayo OI; Adebayo ET
    Background . Changes occur in the heart's contractile and metabolic demands during altered thyroid states. The changes may be associated with alterations in the cellular signaling of vascular endothelial growth factors (VEGF) and expressions of heat shock proteins (Hsp). Aim . This study examined the effects of thyroid dysfunction on VEGF, hsp70, and hsp 90 concentrations in the heart tissues of dysthyroid rats. Methods . Wistar rats were allocated into control, hypothyroid (Carbimazole-treated), and hyperthyroid (Levothyroxine-treated) groups randomly (n=7). Thyroid function test, body weight changes, serum creatinine kinase (CK-MB), cardiac troponin I (cTnI) and troponin T (cTnT), NO, VEGF, Hsp70, and Hsp 90 were determined using standard methods. Results . There was a significant increase (P<0.05) in NO, VEGF, Hsp70, and Hsp 90 levels in the hyperthyroid group and reduced expression in the hypothyroid group compared to the control. Carbimazole treatment led to a significant increase in lipid peroxidation and CK-MB level, with a substantial decrease in the superoxide dismutase (SOD) activity in the hypothyroid group. Conclusion . Increased expression of Hsp70 and 90 in hyperthyroid rats' heart tissue play essential roles in protecting the heart from oxidative damage and cardiovascular derangements via enhancement of nitric oxide production and apoptosis inhibition by VEGF.