Dietary composition modulates impact of food-added monosodium glutamate on behaviour, metabolic status and cerebral cortical morphology in mice

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dc.contributor.authorOnaolapo AY
dc.contributor.authorOdetunde I
dc.contributor.authorAkintola AS
dc.contributor.authorOgundeji MO
dc.contributor.authorAjao A
dc.contributor.authorObelawo AY
dc.contributor.authorOnaolapo OJ
dc.date.accessioned2022-07-27T19:26:28Z
dc.date.available2022-07-27T19:26:28Z
dc.date.issued2019
dc.descriptionBiomedicine & Pharmacotherapy
dc.description.abstractEffects of food-added monosodium glutamate (MSG) on neurobehaviour, serum biochemical parameters, malondialdehyde (MDA) levels, and changes in cerebral cortex, liver and kidney morphology were assessed in mice fed standard diet (SD) or high-fat diet (HFD). Animals were assigned to 8 groups [SD control, HFD control, and six groups fed MSG plus SD or HFD at 0.1, 0.2 and 0.4 g/kg of feed]. Animals were fed for 8 weeks, behavioural tests were conducted, and blood was taken for estimation of biochemical parameters and MDA level. Whole brain was homogenised for neurochemical assays, while the cerebrum, liver and kidneys were processed for histology. In groups fed MSG/SD, there was a decrease in weight gain, increase in food-intake, an increase in locomotion, a decrease in rearing/grooming, and a decrease in anxiety-response. Also observed were derangements in biochemical parameters, increased MDA, and alteration of renal morphology. Compared to HFD, MSG/HFD groups had reduction in weight gain, food-intake, grooming and anxiety-response, an increase in locomotion, and improved memory. Protection against biochemical derangements and HFD-induced organ injuries were also observed. In conclusion, the findings suggest that possible interactions that may occur between dietary constituents and MSG are determinants of the effects of food-added MSG in mice.
dc.identifier.citation10.1016/j.biopha.2018.10.172
dc.identifier.issn0753-3322
dc.identifier.urihttps://nerd.ethesis.ng/handle/123456789/403
dc.language.isoen
dc.subjectBehaviour
dc.subjectBrain
dc.subjectDysmetabolism
dc.subjectDyslipidaemia
dc.subjectDiet
dc.subjectFood additive
dc.titleDietary composition modulates impact of food-added monosodium glutamate on behaviour, metabolic status and cerebral cortical morphology in mice
dc.typeArticle
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